KV raised its price 100-fold, driving the cost of a full treatment to $25,000, from $250, and ending access to the treatment for thousands of women.
Its manufacturer took advantage of its exclusivity period to raise its price 100-fold, driving the cost of a full treatment to $25,000, from $250, and ending access to the treatment for thousands of women.
The dissociation constant for binding of Zn II) to each peptide (Cys4, Cys3His, and Cys2His2 sites) is the same, 0.5 pM, with the same −16.8 kcal mol 1 energetic contribution to the protein folding driving force from metal binding.
These transiently and sparsely populated species on the protein folding energy landscape play crucial roles in driving folding toward the native conformation, yet some of these nonnative states may also serve as precursors for protein misfolding and aggregation associated with a range of devastating diseases, including neuro-degeneration, diabetes and cancer.
Among the social disorders associated with alcoholism are 2- to 10-fold increases in driving and sexual offenses, petty crime, child and spousal abuse, and divorce.
"Consumers who are active in digital media creation and consumption will witness their digital media storage needs grow nine-fold by 2014, driving the demand for higher capacity, easy-to-use storage solutions".
Binding of extracellular calcium ions to repeats emerging at the bacterial surface then 'turns on' structuration of the repeats, pulling the protein out of the cells and driving folding of the rest of the protein.
For MFS5 promoter- gfp fusions, transcription of the reporter gene was strongly influenced by the strain background with both G186A and G217B MFS5 promoter sequences driving 2.0-fold to 3.0-fold more transcription in the G186A background.
The arrangement of secondary-structure elements suggests that the passenger can fold sequentially, providing the driving force for passenger translocation.
When one Kansas City-based truck driving school folded in disgrace shortly after I left Sallie Mae, I wasn't surprised.
ICP0 was first identified based on its capacity to transform HSV's major transcriptional regulator, ICP4, from a weak transcriptional activator to a potent activator of mRNA synthesis; specifically, combinations of ICP0 and ICP4 are 20-fold more potent at driving mRNA synthesis than either ICP0 or ICP4 alone [5], [6].
