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The two fold dose increment that we did in this study does not seem to be necessary to achieve adequate plasma concentrations.
After more than 6-fold radiation dose reduction by simply lowering the tube current, we observed a good correlation between the mean measurement values in LD and the ULD (more than six fold dose reduction), but a high level of noise in the ULD images which did not allow sufficient calculation of brain perfusion maps.
Efficacy of the trimodal treatment was significantly greater than that achieved with bimodal- or individual treatments with potential for 10-50 foldosese reduction compared to that required for individual treatments.
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A two-fold dose escalation gave a 2.4-fold increase in the total AUC.
The greater immune response achieved by high expression was maintained over a 100-fold dose range.
At 22 d of age, all the experimental groups except for NC were challenged with 50-fold dose of Livacox T as a trivalent live attenuated coccidiosis vaccine.
β-Endorphin displayed only limited effectiveness in causing prolactin release when tested over this 30-fold dose range, compared to loperamide or fentanyl.
On day 18, all experimental groups except for the negative (group 1) were challenged with 10-fold dose of Livacox T™ to produce a mild coccidiosis infection.
Conversely, technologists had a great impact on radiation dose, both in terms of median and IQR, with DLP values varying from 580 mGy∙cm to 1,047 mGy∙cm, associated with an approximately ten-fold dose variation for the same kind of CT examination (lowest and highest observed values: 202÷1,970 mGy∙cm, P < 0.001).
In contrast-enhanced whole-body CT studies, the influence of radiologists on the radiation dose was determinant, with median values going from 1,300 mGy∙cm to 3,253 mGy∙cm and a 27-fold dose variation between the lowest and the highest observed values (357÷9,578 mGy∙cm, P < 0.001).
We found that rats immunized with MNs containing low-dose OVA (approximately 200 μg) had persistently high antibody levels for 18 weeks, which were significantly higher than those observed after an intramuscular injection of full-dose OVA (approximately 500 μg), demonstrating at least 2.5-fold dose sparing.
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