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SMAR1 overexpression in 293 cells resulted in upto 3 fold decreased p53 acetylation (Figure 4G).
Bet v 1.0401 batch B showed only a 2 fold decreased allergenic activity when compared to Bet v 1.0101.
Unexpectedly, thrombin-stimulated PP1cγ −/− platelets showed a maximum of ∼1.9 fold decreased GSK-3β-Ser9 phosphorylation (6A and 6C).
Q73 mHttex1-split-GFP exhibited a four fold decreased mobility relative to intact Q73-GFP (mean D± standard errors of 22.8±0.7 vs. 6.5±0.5) (Fig. 4E).
However, in contrast to Cldn13, Cldn5 expression remained low (1.4 to 2.1 fold decreased at day 17 compared to day 0, p≤0.03) throughout the experiment (Fig. 5C).
AIP1 expression levels were around three fold decreased in GABI_465B06 homozygote plants (here denoted as AIP1KD) (Fig. 9b).
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Testing of the analogs in ovarian cancer cell lines demonstrated 100 1000-fold decreased antiproliferative activity.
Lithium treatment in 100 patients with affective disorders was associated with a 6-fold decreased incidence of suicide attempts.
The first virus, which had K20I, M36I and V82I, showed 2.9-fold decreased susceptibility to APV, while the second virus showed 3.9-fold decreased susceptibility to both NFV and RTV, with amino acid substitutions K20I, M36I, L63P and V82I.
Placement of Cys at one of these positions altered Km(pro) (S332C and L346C, 3- and 21-fold decreased, respectively; Q345C, 38-fold increased), K0.5(Na+) (S332C, 13-fold decreased; Q345C, 19-fold increased), and/or Vmax [G328C, S332C, Q345C, and L346C, 3-, 22-, 2-, and 8-fold decreased compared to PutP wild type), respectively].
Compared to [68Ga]pentixafor, total cellular uptake and internalization efficiency of [68Ga]NOTA-pentixafor in CXCR4+ Chem-1 cells are 2.6- and 7.9-fold decreased, respectively.
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