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Our group is broadly interested in understanding how metazoan cells fold complex proteins.
This unusual mode of ATP utilization likely serves to orchestrate a directional mechanism underlying TRiC/CCT's unique ability to fold complex eukaryotic proteins.
The principle conclusions are that the fold of the protein is that of a degenerate GTPase and is required for the formation of a larger "HIKM" complex that acts upstream of several other CCAN components, notably the TWSX histone fold complex.
Similar(57)
Yan, Z. et al. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.
Unlike the less-evolved bacterial cells, algae are particularly good at folding complex proteins.
A peptide loop around this amino acid appears to be important for the formation/stability of the fully folded complex.
Based on our results, we believe that it is possible to use active materials to develop reprogrammable self-folding complex structures.
This shows the fitness of the C. reinhardtii chloroplast for the expression of properly folded complex proteins.
The superficial urogenital sinus-genital folds complex is the primordia of the external urogenital sinus compartment, which originates the vulvar structures except the labia majora (Fig. 12).
The superficial urogenital sinus-genital folds complex primordium originates the genital tubercle and cloacal folds; b Week 12: the urethral folds arise from the cloacal folds and the urethral groove from the cloacal membrane; c Week 14: compartments are already formed.
As seen in Table 1, we obtain 95 100% correctly folded complex and these HC were 97 100% biotinylated.
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