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We focussed on modifying the 5-position substituent (R) to investigate the interaction with the gatekeeper residue (Phe 80 in HsCDK2), and the amide (R) to probe the lipophilic pocket along the backbone of the kinase.
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For hanging suicides, one potential solution for reducing these suicides would be focusing on modifying the anchor points from which people hang themselves on.
Most remedies focus on modifying Microsoft's behaviour.
It focuses on modifying mortgages primarily by reducing interest rates so homeowners can meet monthly payments, but the program's mandated process fails to require mortgage servicers to consider writing down principal.
Critics worry that the method focuses on modifying the symptoms rather than addressing the underlying disabilities, and many say they fear that A.B.A.-trained children often do not "generalize," that is, take a behavior learned in one setting and apply it in another.
"We need to really focus on modifying the law so we could maybe include this as a day for education and not a day off for two boroughs," said Mr. Walcott, who oversees city education policy and whose boss, Mayor Michael R. Bloomberg, has been known to complain that public school students do not spend enough time in class.
The first approach focuses on modifying the aggregate types and amounts.
Future work should focus on modifying these structures to narrow the acceptance angles.
A substantial amount of research has been focused on modifying the TiO2 photocatalyst for enhancing pesticide degradation [22].
Many investigations have focused on modifying the nanostructures of TiO2 photoelectrodes to nanospheres, nanospindles, nanorods, nanowires, and others[16 20].
Many researches focus on modifying present rectifier and voltage multiplier topologies to achieve higher gain, sensitivity, efficiency [52, 55 57, 61].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com