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3. Focusing on trials might be the wrong thing to focus on.
However, we have identified no study focusing on trials of anticoagulation in patients with cancer.
We limited this source of bias by focusing on trials for which registration was not delayed.
35 36 In response to reviewers' comments, we added a sensitivity analysis focusing on trials with interventions specifically chosen to raise high density lipoprotein cholesterol (fibrates and niacin combinations) and another focusing on trials that reported intention to treat results.
When we conducted a systemic review of frailty intervention focusing on trials that measured outcomes based on their pre-defined frailty indicators, only 11 studies were included [ 5].
When focusing on trials with appropriate allocation concealment (category 1 and 2) versus trials with clearly inappropriate methods of concealment (category 4), the difference was not statistically significant (ES=0.26; 95% CI −0.04 to 0.55).
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The analysis was only focused on trials that considered as outcome measure an improvement of at least one class on the NYHA classification or on the LVEF.
In this review, I focus on trials examining therapeutic cancer vaccines at different stages of existing disease.
This review focusses on trials designed to test safety and/or efficacy of targeted therapies in osteoarthritis.
These reviews focused on trials sponsored by the pharmaceutical industry.
Also, our study focused on trials, which constituted the units of our analysis.
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