Hereafter, we focus on specificity of impacts (i.e. skew in performances across affected victims isolates).
A quality pre-screening test will focus on sensitivity while a quality serological test will focus on specificity.
Initially, attention focused on specificity and affinity, with the selection of mAbs being based primarily on their ability to inhibit tumour cell growth in vitro.
While SI and KLAS presented very similar values - with KLAS showing a slightly better result - ARH was more focused on specificity.
It is important that future efforts also focus on specificity issues including possible off target effects such as unspecific trans-splicing, and cryptic cis-splicing or undesirable translation from within the RTM (Gruber et al., 2013, Monjaret et al., 2014).
Following this exercise, sensitivity of the expanded Approach 3 was improved: 0.581 (0.558 – 0.605) compared to 0.48 (0.456 – 0.504) for the original Approach 3. The specificity of the updated Approach 3 was reduced: 0.558 (0.527 0.58989) compared to 0.62 (0.59 – 0.65) for the original Approach 3. Changes to the algorithm focused on specificity also can be identified and implemented.
Since then, most ecologists, biological control practitioners and regulators tend to focus on specificity not primarily because of its link to effectiveness but because it lessens the possible ecological risks associated with the introduction of natural enemies, often non-native, in the environment.
Due to this short consultation time, i.e. 7.08 ± 6.28 minutes [ 19], it would be reasonable to expect poorer GP-patient communication, which is less focused on specificities.
Here, we critically evaluate the robustness of the current evidence in humans, focusing on the specificity, replicability, and the relationship of the reported changes with behavior.
Here we review current insights into the functional role of HATs, focusing on the specificity of their action.
