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There has been no systematic study focusing on dosage compensation in mosquitoes.
Despite the presence of previous studies [ 8, 9] focusing on dosage variations of individual genes, there is very little work [ 10] approaching this question from the gene network point of view.
Another study focusing on dosage imbalance in S. cerevisiae investigated the cell cycle genes and the robustness or fragility of the metabolism in response to over-expression of single genes.
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The study focused on dosage, charting how the risk of weight gain increased with the build up of the drug within the participant's body over the course of a regular treatment regimen.
These findings from the Longitudinal Study of Australian Children (LSAC) were irrespective of ECEC quality, which was not assessed within the LSAC study, emphasising the importance of focussing on dosage issues in ECEC provision when considering children's cognitive outcome effects (Coley et al. 2015).
In this study, we focused on dose and dosage interval selection.
By focusing on evolution-related dosage imbalances, our results corroborate this hypothesis.
Indeed, the dosage of 5 mg was abandoned and further investigations focused on the dosage of 1.25 mg and 0.5 mg.
Much effort is thus focused on developing dosage forms that can be administered less frequently.
Finally, we have focused on gastroretentive dosage forms especially designed against H. pylori, including specific targeting systems against this bacterium.
Recent research on the efficacy of chloroquine has focused on the dosage used to treat acute CHIKV infections [ 38, 39].
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