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Firstly, PRISMA focuses on efficacy; thus measurement of its effect would reasonably focus on systematic reviews of efficacy and not specifically of harms.
Others have pointed out that there is very little research which focuses on efficacy research (testing interventions in a controlled setting) or implementation research – the "how" of translating current research knowledge into practice within existing health and social systems [ 6, 7].
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We reviewed the most recent literature on colistin treatment, focusing on efficacy and toxicity issues.
Several randomized clinical studies have focused on efficacy and safety issues [25].
Once you've finished the integration, you can focus on efficacy.
Previous studies on epidural injections have focused on efficacy and have not evaluated factors predicting outcomes of epidural injections.
To study treatment modalities for cesarean scar pregnancies (CSPs), focusing on efficacy and complications in relation to study quality.
This clinical trial focused on efficacy and did not investigate end-points relating to mode-of-action of the vaccine.
While most of the research on internet-based cognitive behavior therapy (iCBT) has focused on efficacy and effectiveness only little attention has been devoted to the implementation of iCBT.
Most of the systematic reviews focused on efficacy or effectiveness.
Thus far, PRISMA has mainly focused on efficacy and not on harms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com