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AECG = American-European Consensus Group; cFS = cumulative FS; CI = confidence interval; FS = focus score; MSGB = minor salivary gland biopsy; ROC = receiver operating characteristic; SE = standard error; SS = Sjögren's syndrome.
The three criteria, Bm2+Bm2′/eBm5+Bm5 ⩾5, anti-SSA and/or anti-SSB, and focus score ⩾1, were ranked in a classification-tree (fig 3).
In the digital pathology pipeline, tumour localisation is essential to focus scoring of cellular proteins to particular regions of interest.
Focal sialadenitis with higher focus score was characteristic of primary Sjögren's Syndrome.
Scoring of histological sections was based on the focus score used in patients with SS [22].
SG inflammation was evaluated by focus score and immunohistochemical quantification of infiltrating cell types.
In general, SJL/J mice showed low-grade local inflammation, as reflected by the focus score (average 0.39) at baseline.
In addition, immunization with a modified Ro60 peptide, MAP-Ro60, does also not lead to an increased focus score.
Despite the observed reduction in focus score, stimulated salivary flow was not improved in early treated mice.
The focus score was considered abnormal if it was ≥1.
Lip biopsy focus score was recorded from the medical files.
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