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The position of the pancreas in the abdominal cavity makes it a difficult target for focused radiotherapy, but a procedure using radiotherapy simultaneously with surgery permits the surgeon to focus radiation directly onto the pancreas by moving obstructing organs aside.
Focal high-dose radiation reduces toxicity to non-neoplastic tissue, but tumor invasion into normal brain regions limits the survival benefit of highly focused radiotherapy techniques, like gamma knife and proton beam, establishing a need for improved combinatorial treatments, such as radiosensitizers.
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Additionally, mp-MRI can be used to help nerve and continence sparing surgery, and to focus radiotherapy.
Conformal radiotherapy usually focuses radiation on only a small part of the liver.
The work focused on radiotherapy and palliation, cancer surveillance, prevention, and early detection as well as strengthening civil society and community support for cancer control [ 11].
For example, a fairly recent health technology assessment report from AHRQ in the United States focused on radiotherapy, but also presented results from nine randomised trials which had made 9 different comparisons for second- or subsequent-line treatment of SCLC[ 8].
Radiotherapy focused on tumor reduction was defined as radiotherapy with a radiation dose >30 Gy, excluding palliative radiotherapy for bone metastases.
The discussion focuses on radiotherapy techniques (Chapter 10) and neuropsychological outcome (Chapter 11).
Although a few studies have focused on palliative radiotherapy for these patients, no controlled trials have been conducted.
Only few studies have focused on palliative radiotherapy used for patients who weren't suitable for resection by surgery.
Our sample comprised 50 GBM patients in a retrospective analysis of three prospective studies that focused on combined radiotherapy and required MGMT promoter-status testing as inclusion criteria.
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