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Most of the reported modification studies on the key α,γ-diketo acid pharmacophore focused on substituting the carboxylate moiety with its bioisosteres or other electron-pair bearing heterocycles.
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This work focuses on substituting a computationally expensive simulator by a cheap emulator to enable studying applications where running the simulator is prohibitively expensive.
Specifically, we focus on substituted phenols, because they are the most common test set molecules employed in the evaluation of novel p K a prediction approaches [21 24, 56 58].
In Oregon, legislators recently passed the eighth in a series of bills focused on substitute teachers, setting pay scales at 85percentt of a district's average teacher salary.
However, research has largely focused on cycling substituting motorised transport.
Therefore, the present article reviews studies focused on seeking substitutes for L-asparaginase through alternative sources including bacteria, fungi, actinomycetes, algae and plants to overcome these limitations.
Much of the public and political debate on global warming has focused on finding substitutes for fossil fuels, reducing emissions that contribute to greenhouse gases and furthering negotiations toward an international climate treaty — not potential security challenges.
The following review focuses on hydroxyapatites substituted with ions with antibacterial properties.
Additionally, public economics literature defines differential incidence as that in which analysis is focused on the economic effects of substituting one tax by another, leaving total revenues constant.
So the focus is more on substituting the right kinds of food to eat". But, she said, finding time for exercise if you already have a busy schedule can be challenging.
"Up until now, science was much more focused on finding the synthetic substitutes in beauty," said Shirin Valipour, a 24-year veteran of the beauty industry who started Orico, an organic skin-care brand, in London last October.
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