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In this study, we focused on dose and dosage interval selection.
Prospective trials aimed to improve the RR, time to progression (TTP) and survival have focused on dose intensification of cisplatin in combination with VP16.
To overcome this problem, we have strived to use a consequent language (Table 1), focused on dose distribution plots and not concentration-time plots (as discussed above).
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In humans, numerous studies have sought clinical correlates, but few have focused on dose-related effects, especially as regards neurologic function beyond the neonatal period.
Generally, those approaches focused on dose-response relationships over an entire year.
We have focused on doses likely to be used in clinical practice, namely 10 mg/day for dapagliflozin.
For this reason we focused on doses of 267 and Dt below that which caused 50% toxicity over the 72-hour incubation time.
Similarly, and more directly focused on doses from medical imaging, the American Association of Physicists in Medicine (AAPM) has stated, "Risks of medical imaging at effective doses below 50 mSv for single procedures or 100 mSv for multiple procedures over short time periods are too low to be detectable and may be nonexistent.
However, much of this literature has focused on short term, high dose exposure scenarios often conducted in model media.
In this brief review, we summarized the recent advances in nanotoxicological chemistry through the dissection of pivotal factors (primarily focusing on dose and nanosurface chemistry) in determining nanomaterial-induced biological/toxic responses with particular emphasis on the nanomaterial bioaccumulation (and interaction organs or target organs) at intact animal level.
The guidance documents identified were reviewed and a selection was compared for type of guidance (clinical/technical), technology and proposed QA methodologies focusing on dose and image quality (IQ) performance assessment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com