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These numbers indicate a general downregulation of the entire transcriptome, combined with a focused induction of a specific set of damage response genes, lexA dependent and others.
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The general earlier induction, the focused earlier induction of women with body mass index >30, twins, and of women above 40 years and a halving of smoking pregnant women were all independent contributing factors for the decrease.
WHO recognizes the crucial role of misoprostol in reproductive health and has incorporated recommendations for its use into 4 reproductive health guidelines focused on induction of labor, prevention and treatment of postpartum hemorrhage, and management of spontaneous and induced abortion.
Although most HIV-1 infections worldwide result from heterosexual transmission, most vaccine candidates have focused on induction of systemic immunity and protection.
However, while much of the previous work focused on induction of mitochondrial oxidative stress by dioxin, we did not find a strong transcriptional signal indicative of such a stress, despite the deliberate inclusion of a manually-assembled antioxidant response element network into the interactome analysis.
Next, we focused on induction of PUMA as the cell death mechanism.
This study demonstrated that CM focused on induction of chondrogenic differentiation while IM was in favor of promoting proliferation and expression of endochondral ossification related genes.
Many researches have been focused on induction of cellulase and xylanase production by different monosaccharides, disaccharides, and carbohydrates used as sole carbon source [ 16].
Some studies focused on induction of gene expression by overexpressing PAX3-FKHR in a non-ARMS background, however, ectopic expression of PAX3-FKHR might not lead to induction of endogenous PAX3-FKHR target genes in a non-ARMS environment.
Efforts have focused on induction of endogenous IFNγ by natural killer (NK) or T cells following stimulation with cytokines IL-2, IL-12, IL-15, IL-18, and IL-21, which have been used individually or in different combinations [ 9– 13].
Béraud et al. emphasized the importance of protein misfolding, oxidative stress, and inflammation in PD as a potential locus for the development of novel therapeutics focused on induction of the Nrf2-directed antioxidant pathway and inhibition of protein misfolding [ 123].
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