This unique fluorescent probe was successfully applied to the screening of a kinase focused compound library.
In this work, five focused compound libraries based on the chemical structure of MI-2 are designed and synthesized.
In each case, three to four times more hits were obtained from the focused compound set than from the random compound set.
Here we report the construction of a focused compound library of 1,2-benzisoselenazol-3(2H -one derivatives which comprise a total of forty-six candidate compounds.
In the context of virtual screening calculations, a multiple fingerprint-based metric is applied to generate focused compound libraries by database searching.
Contemporary small molecule drug discovery often relies on high-throughput screening (HTS) of either structurally diverse or mechanistically focused compound library sets to identify hits that have the potential for multiparameter optimization against biological targets of interest.
With the availability, for the first time, of a stable and soluble form of ANAT we can now report the identification of initial inhibitors against this biosynthetic enzyme, obtained from the screening of several focused compound libraries.
To improve the pharmacokinetic properties including metabolic stability and enhance the anticancer activities, a focused compound library by altering this sensitive metabolic region of mifepristone has been designed and synthesized for scaffold repurposing and structural optimization.
In this article, refinement of the initial hit XDW-1 by synthesis and screening of a focused compound library led to the identification of a novel set of imidazopyridine derivatives as potent CDC25 inhibitors.
We used a rational design approach based on analysis of combinatorial peptide mixtures and focused compound libraries to develop novel peptide hydroxamic acid inhibitors of IDE.
The MRCT ion channel focused compound file was selected in collaboration with the Dundee Hit Finding Unit and consisting of ∼ 4,000 compounds.
