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In these cells, a single Spc110-YFP focus was observed, providing evidence that Ndc1 localizes to the new SPB before insertion into the NE.
One prefrontal activation focus was observed in the ventrolateral prefrontal cortex (VLPFC) in the vicinity of the frontal operculum of the left hemisphere.
A single Spc110-YFP focus and a single Ndc1-mTurquoise2 or Nbp1-mTurquoise2 focus was observed in Ndc1-mTurquoise2/Spc110-YFP or Nbp1-mTurquoise2/Spc110-YFP strains arrested in α-factor and at the 5 min time point following release.
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Prominent seasonal variations in the Sq focus latitude, as well as in the local time of Sq focus, are observed.
However, after crossing over (in late pachytene and early diplotene), no effect of RAD54/RAD54B deficiency on the reduction of irradiation-induced foci was observed.
In addition, inter-subject variability in the progression with different focuses was observed, with one patient developing a non-fluent PPA variant.
After MMC, a similar proportion of cells with γ-H2AX foci was observed in control and p210-transduced cells (Figure S2).
Thus, a marked increase in DNA damage foci was observed in both proliferating and differentiating Chk1+/− erythroid progenitors during erythropoiesis, whereas WT erythroid cells did not display DNA damage foci.
Under these treatment conditions, a significant increase in the percentage of cells with Rad51 foci was observed.
An emergence of small, pyroninophilic ('tigroid') foci was observed at the second, fifth and eighth days after the proliferative stimulus.
A dose-dependent induction of γH2AX foci was observed in round spermatids, but in elongated spermatids and spermatogonia stem cells (SSC), γH2AX foci were not formed.
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