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The two new sections were blindly examined by the same pathologist, who again recorded the area and the focus score for each level.
ACA; anti-centromere antibody, FS; focus score For comparison to ACA+ pSS patients, 48 pSS patients in the absence of ACA were selected to be the conventional (ACA-) group for pathological study.
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Although the addition of PTX to MAP-Ro60 immunized mice compared to PBS controls tended to increase the mean focus scores for the tailbase (0.88 versus 0.42, p = 0.15) and abdominal area (0.59 versus 0.36, p = 0.20) injection sites, this increase did not reach statistical significance (Figure 3).
Mukherjee [ 7] used a quantitative approach, calculating focus scores for one plant, based on volume and variety of products and parts.
Pesch and Schroeder [ 39] used a mixed approach, calculating degree of focus scores for multiple plants, based on a questionnaire investigating variety in products, volumes and competitive priorities.
Morphological evaluation of induced liver fibrogenesis was performed using the semi-quantitative fibrotic focus score proposed for staging and grading of histopathological lesion of chronic hepatitis in humans [ 23].
The American-European Consensus Criteria for the classification of SS finally established that, among the six items composing the criteria set, either focal sialoadenitis at MSG biopsy (with a focus score ≥1 for 4 mm2 glandular tissue) or the presence of specific autoantibodies should be mandatory for the diagnosis of pSS [ 10].
N = 103 for focus score data among the 122 follow-up patients, other variables had larger samples.
Pilocarpine stimulated saliva flow was measured to address the salivary gland function and salivary glands were analyzed for focus score and cytokine profiles.
The specimens from pSS patients showed characteristic features (for example, focus score ≥1 and presence of lymphoepithelial lesions) whereas those from non-pSS sicca and control subjects did not show any such characteristics.
Approximately 40 doublets with foci and 40 doublets without foci were scored for clonogenicity.
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