And scientists are discovering that even after the multitasking ends, fractured thinking and lack of focus persist.
However, in G6PD silenced cells a fraction of γH2AX foci persisted confirming a defect in DSB repair.
However, 53BP1 and γ-H2AX foci persisted 24 h post-RK-33 treatment, indicating reduced or delayed DNA repair (Fig 9A).
Consistent with the recent discovery that telomeric DSB's resist DNA repair (Fumagalli et al, 2012), our data demonstrate that telomeric DDR foci persisted in cells lacking hTERT activity while non-telomeric foci were resolved within days.
In late pachytene stage, however, RAD-51 foci persisted in pgl-1 mutants that exhibited SYP-1 aggregates, whereas they disappeared in wild-type worms that did not show SYP-1 aggregates.
Third, we observed that HRR of seDSBs as measured by SCEs is not impaired by the absence of ATM, even though Ku foci persist under these circumstances.
Plague-endemic foci persist in Africa (the most affected continent), Asia, South America, and North America (5 ).
Currently, plague natural foci persist in Asia, the Americas, and Africa (where most human cases occur) (1 ).
These telomeric DDR foci persist suggesting that also oncogene-induced telomeric lesions are not efficiently repaired.
In C. elegans smc-5 / 6 mutants, RAD-51 foci persist, and chromatin bridges are formed during ensuing mitosis.
