I wish you would focus on trail-blazers and pioneers, not on those among us who prefer to look backward instead of forward.
The focus on TRAIL as a potential therapeutic agent became obvious owing to its differential sensitivity to observe between normal and cancerous cells (Ashkenazi et al, 1999; Walczak et al, 1999), while its major advantage lies with its ability to trigger tumour cell apoptosis in a variety of cancers independent of p53 status (Pitti et al, 1996; Galligan et al, 2005).
Thus, we focused on TRAIL, the involvement of which in hypoxia-induced apoptosis of cancer cells had been reported.
In contrast to our study, Herold et al focused on TRAIL-expressing Gr-1int cells which would exclude some of the CCR2-dependent TRAIL-expressing populations assessed here (Ly6Chigh cells).
Since this study focuses on TRAIL-induced programmed necrosis as a novel approach to eliminate tumor cells, we explicitly want to point out that TRAIL-induced programmed necrosis in principle occurs under the condition that the normal apoptotic pathway is inhibited.
Bullishly inclined brokers will not be able to wriggle out from the force of this conclusion by focusing instead on trailing reported earnings.
The new effort to work with America's former adversaries in the campaign against terrorism arises as the F.B.I. has begun to run out of leads at home in its investigation of the September attacks and finds that it has to focus on following the trails of the hijackers and their accomplices overseas.
Our work in the future will focus on using audit trails in investigations of students learning processes and outcomes in educational multimedia environments.
She also knocked back Barnaby Joyce's suggestions that Tony Abbott harboured ambitions of a comeback labelling it "horseshit" and saying Joyce needed to focus on the wombat trail (the traditional name for the Nationals' campaign).
Rep. Tim Huelskamp (R-Kan)., a member of the conservative Freedom Caucus, argued that the shift in focus on the campaign trail from candidates like former Florida Gov. Jeb Bush -- who shares the name of two of the last four presidents -- to a TV entertainer, former Hewlett-Packard CEO, and former neurosurgeon, is a sign of where the party needs to head.
