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On the one hand, this review will focus on compounds which are already in clinical studies and, on the other hand, highlight most recent aspects of the preclinical development of tracer targeting these integrins.
In the following sections, we discuss the general mechanisms underlying collateral sensitivity and focus on compounds reported to elicit increased toxicity in cells overexpressing one of the three major multidrug transporters.
At first, the algorithms were trained with a focus on compounds with a single-target activity.
Since we wanted to focus on compounds with structures, only records with MOL file representations of chemical structures [23] were extracted.
Prebiotic chemists tend to focus on compounds which are present in modern biochemistry, ignoring the large fraction of compounds found in meteorites or produced in simulations that are not found in biology.
Instead the search should focus on compounds that show a reduced effect on the expression of these IR genes.
Similar(51)
Several applications of SVMs have been reported that focus on compound ranking in similarity searching [4 6].
In this review, we focus on compound screens performed in the nematode worm, Caenorhabditis elegans.
The interventions focus on compound-level modifications because we assume that the dominant transmission pathways for the infants in our study will be within the compound.
This process may reduce to the same "order for free" tendency that Thompson and Kauffman focus on, compounded at many levels over time.
Activity cliff analyses by their algorithmic nature focus on compound pairs, in this contribution so-called matched molecular pairs with a size-restricted transformation accounting for a single structural difference between the two cliff-forming compounds.
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CEO of Professional Science Editing for Scientists @ prosciediting.com