As a result, recent research has focussed on a refinement of predictive classifiers from well-characterised, rather than clinically heterogeneous, patient cohorts.
A design-based research (DBR) methodology (Edelson 2002) guided the design process, yet with a focus on the refinement of a central, theoretical concept, that of 'citizen inquiry', and its instantiation in educational technologies, rather than the production of domain theories, design frameworks, or design methodologies.
Thus, this study reports the first stage of evidence generation, with a focus on development, refinement and feasibility testing, which may lead to further quantitative testing of the effectiveness of the intervention.
In this review, we focus on a further, relatively unexplored refinement of the amyloid cascade hypothesis – namely, the idea that certain pools of Aβ are more relevant than others to the pathogenesis of AD.
Future work should focus on further refinement of these techniques in an effort to improve the outcomes, along with successful translation to humans.
Documenting questions as they are asked also provides both authenticity and subsequent opportunity to focus on refinement and/or reformulation (a later stage of activity associated with the QFT).
We focus on mesh refinement for moderate (p="3) and high order (p= 6) elements.
Future work will focus on the refinement of the system architecture and incorporation of recent advances in optimisation, e.g., particle swarm optimisation (PSO) and related methods.
The evolution of Y2O3 during mechanical alloying (MA) and subsequent annealing were studied with the main focus on the refinement of particle size by the addition of minor alloying elements.
Additional study should focus on technical refinement, anesthesia optimization, and patient selection in effort to increase in-office ESS tolerability.
