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Note that additional highly connected non focus molecules are also included.
The highest scoring network (Figure 1) incorporated 18 out of the 24 differentially expressed proteins (focus molecules) indicated in Table 2, and the second network incorporated 5 focus molecules.
These genes, or focus molecules, were overlaid onto a global molecular network developed from information contained in the Ingenuity Pathways Knowledge Base.
The number one ranked network (score = 62, focus molecules = 33) (Figure 4) is associated with Cardiovascular System Development and Function, Cellular Growth and Proliferation and Cell Morphology.
Focus molecules correspond to the number of genes included in functional network.
Direct and indirect relationships with a maximum of 35 focus molecules per network were included.
Significantly, the network identified with the highest score included CHKA among the focus molecules.
Network analysis by IPA was used to draw connections between interacting focus molecules.
The network with the highest score consisted of 35 molecules in 25 focus molecules and 11 interconnecting molecules.
Of these networks, cell death was the highest rated network with 65 focus molecules and the significance score of 44.
Box sizes correspond to the number of focus molecules and the color intensity is the –log p-value).
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