Although the development and testing of the first-generation DESs focused to a considerable degree on efficacy parameters, including restenosis, recent concerns over late clinical events have prompted a refinement of the design criteria for succeeding generations of these devices.
Bioreactors have therefore been in focus for a considerable time to build up enlarged tissues.
The estimation and removal of the CFO has been the focus of a considerable number of works published in recent years.
Partly because he was a masterful stylist and wrote delightfully beautiful Sanskrit verse, and partly because his work exerted a strong influence on Tibetan Buddhism, Śantideva has been the focus of a considerable amount of modern scholarship in Japan, Europe and North America.
Benzylisoquinoline alkaloid (BIA) metabolism has been the focus of a considerable research effort over the past half-century, primarily because of the pharmaceutical importance of several compounds produced by opium poppy (Papaver somniferum).
Sampling technique for earthworm studies is the focus of a "considerable debate" (Spurgeon & Hopkin 1999: 182) and there are obviously advantages and disadvantages of each method.
Vernalization is also the main parameter involved in flowering time regulation in Easter lily and therefore has been the focus of a considerable amount of research related to physiological aspects of this species' development, in order to reach flowering at specific dates [ 3, 5].
However, as plague evidently has not been able to persist indefinitely in European hosts, it is notable that plague died off in rural Europe under periods of decreasing predicted plague peaks and virulence in Central Asia, though several European cities continued to act as independent plague foci for a considerable time, possibly due to the urban rodent reservoirs [ 8].
This kind of comment suggests how and where small changes can be focused to make a considerable difference to patient experience.
This study was mainly focusing to help a considerable percentage of chronic HCV patients who are facing the situation of contraindication, intolerability or non-response to the current gold standard therapy.
