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In a liver with 111In-octreotide-positive tumours, the distribution of uptake foci will be shifted towards higher ThI, due to the merging of uptake foci in the tumour area (a d).
Moving to the right, more and more foci will be included (normalized number of uptake foci on the y-axis) until a threshold is reached (c), just before the number of foci increases and the noise is included (d).
The uptakes are not easily visualized without knowledge of the localisation site, but due to the multiple small uptake sites the distribution of uptake foci will be shifted towards higher ThI (a-c), resulting in a nNUFTI-positive liver for patient number 32F.
One of the main foci will be on three striatal subregions that have central roles in action control by the three circuits.
The identification of proteins sequestered by RNA foci will be a key step in confirming the validity of the toxic RNA hypothesis.
All of the raw data, including the image files and quantified metastatic foci, will be uploaded to the project page on the OSF (https://osf.io/7yqmp) and made publically available.
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