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Microcolonies are foci of cell division and growth within biofilms [7].
Foci of cell mounding, common in CTBE cells but rare in controls, indicate cells with loss of contact inhibition that maintain active proliferation.
Chronic cadmium exposure induced morphological changes, including loss of contact inhibition, atypical foci of cell mounding, and formation of giant multinuclear cells, which are common with cancer cells.
Foci of cell alteration have no obvious disruption of the liver architecture, and the affected hepatocytes merge with adjacent hepatocytes without compressing adjacent normal parenchyma.
Furthermore, several foci of cell loss in the lateral orbital gyrus (area 13) were apparent in case S3, the case that received the most injections into the orbital surface.
The first foci of cell rounding and subsequent shrinkage of the cells were observed on day 2 or day 3 postinfection, when groups of 4 to 8 cells, but also single cells, showed rounding and degeneration; within 1 day the affected cells lost their adherence to the bottom of the flask and floated in the medium.
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Foci of cells were isolated using cloning rings and expanded when possible.
We found that CagA expression was enriched in apical foci of cells we interpret to be photoreceptors due to their apical position within the epithelium (Fig. 6B,C).
All corneas inoculated with HSV-2 ICP0− mutant viruses exhibited at least small foci of cells expressing GFP-tagged, mutant ICP0 (Fig. 5C; n = 25 eyes observed per group).
At this stage there was a change in the hNSCs' adherent properties, and the cells began to grow as a monolayer with multiple foci of cells throughout the culture (Figure 1F).
The medium was replaced every 3 4 days until foci of cells could be identified and expanded.
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