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Intensive public education regarding control measures in areas of known leishmaniasis foci is required.
Recruitment of MDC1 to γ-H2AX foci is required for the formation of MRN, BRCA1, and 53BP1 foci [ 39, 42, 57].
Further investigation of the genetic diversity in the natural and anthropurgic foci is required for the identification of the Leptospira genotypes, control of the strain's transmission, and better understanding of the origin and evolution of the Leptospira species.
Further work to characterize protein binding partners of the RNA foci is required, particularly because many of the studies thus far are in disagreement as to the most important interactions.
The formation of γ-H2AX foci is required for the recruitment of repair-associated proteins such as cell cycle checkpoint protein RAD1, BRCA1-associated RING domain protein 1 (Band1) anDNANA damage-binding protein 2. RAD1 is a component of the 9-1-1 (RAD9-RAD1-HUS1) checkpoint checkpoint response complex that has a major role in DNA damage repair.
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Thus taken together these data support the hypothesis that nuclear foci are required for DM1 pathology to manifest, but may not under some circumstances be sufficient to produce an overt phenotype, when either the CTG tract length, RNA expression levels, stability or context are less than optimal.
This result is in agreement with the second scenario and suggests that the lateral foci are required to support the role of the medial foci during style development.
The Davies review says "further work and a renewed focus is required" to increase women's representation further and have more appointed to chair and senior independent director roles.
Some means of focusing is required; otherwise, a particle that starts out in a direction making a small angle with the orbital plane will spiral into the dees and be lost.
Moreover, the activation uses a two-photon process so a relatively small laser focus is required.
Secondly, a greater focus is required on supporting the detailed design of a fixture's physical structure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com