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Bhogal et al recently showed that γ-H2AX foci incidence in mouse skin exhibited substantial differences between inbred strains, with scid mice exhibiting the highest foci density [25].
To evaluate the appropriateness of the macaque model for γ-H2AX biodosimeter studies in humans, we compared the kinetics of γ-H2AX foci incidence in macaque and human lymphocytes.
These values for γ-H2AX foci incidence correspond to one per 294 cells in control individuals versus one per 37 in obese individuals.
Finally, in one study with obese children, peripheral blood lymphocytes were found to exhibit a greater than 5-fold increase in foci incidence in overweight children and 8-fold in obese children [ 35].
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We also show that γ-H2AX focus incidences partially correlate with cellular proliferation and expression of DNA repair proteins.
One article (3.85%) focuses on incidence, while 5 base their analysis on prevalence (19.23%).
However, as this study focuses on incidence, these factors are less important.
Most previous studies on stroke during pregnancy have mainly focused on incidence and risk factors.
In the current analysis we focus on incidence density to better describe diarrhoea frequency.
We particularly focus on incidence estimates, as this allows us to later explore key methodological issues.
The fetuses at risk approach, with its focus on incidence measures, provides a coherent view of perinatal phenomena.
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