Sentence examples for foci by from inspiring English sources

Recent findings from preclinical studies have demonstrated the predictive potential of DDR foci by correlating foci with clinically relevant end points such as tumor control probability.

In these mice, 8 h after irradiation, early pachytene spermatocytes showed a reduction of the numbers of γ-H2AX foci by 52% compared to 82% in the wild type, the difference being significant.

The ability of CA to modulate the number of aberrant crypt foci by restraining their development and growth and by eliminating a selected population may also contribute to the cytotoxicity of the doxorubicin-loaded micelles[32].

Detection of γH2AX foci by immunofluorescence to observe H2AX foci, was performed as previously described [26].

We quantified the number of BRCA1 and RAD51 foci by counting them in cells having more than twenty H2AX foci.

This knockdown led to a reduction of γ-H2AX foci by >70% in cells treated with radiation (Figure 5D and E).

After irradiation, H2AX is phosphorylated in megabase sized regions at the site of each nascent DSB and can be detected as nuclear foci by specific antibodies.

WSTF does not contain a DNA-binding domain and is recruited to replication foci by binding to PCNA [43]; it can also bind to H3K14-Ac [53].

Formation of secondary metastatic foci by tumor cells requires invading the ECM of secondary organs [26] and inhibiting this invasion is a strategy in cancer therapy that has been widely investigated.

However, microinjection of excess purified Cdc45 into S-phase nuclei activates additional replication foci by three-fold, indicating that Cdc45 functions to activate dormant preRCs and is rate-limiting for somatic replicon usage.

Because small numbers of CD3+ cells had been localized within the inflammatory foci by single-label IHC in the absence of significant CD8 expression, multiparameter IHC and spectral imaging were used to definitively identify the phenotype of intralesional T lymphocytes.