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One additional case showed focal strong expression in 30% of tumor cells.
Tumor cells also showed diffuse immunoreactivity for AFP and focal strong immunoreactivity for hCG.
The expression of αvβ3 was found to be significantly higher in GBMs than in LGGs, whereby focal strong reactivity was restricted to GBMs only.
c-Met immunostaining appeared on the tissue sections as dense cytoplasmic staining, irregularly distributed within carcinomatous cells, with focal strong enhancement beneath the plasma membrane.
In male breast, Gatalica and colleagues [ 16] have reported focal strong PSA expression in normal and hyperplastic ductal epithelium in 5 of 18 cases of gynecomastia.
Anti-CYP19 (Aro 677 -stained sections revealed focal strong cytoplasmic staining of tumour Leydig cells and negative staining of normal tissue sections (Fig. 4).
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Tumours were categorised into five patterns of expression of CA IX: tumour negative, weak diffuse (WD), weak focal (WF), strong diffuse (SD), or strong focal (SF).
Tumours were classified into five patterns of expression: tumour negative; weak diffuse (WD); weak focal (WF); strong diffuse (SD); or strong focal (SF).
This involves the visual detection of focal early, strong enhancement with early washout compared with that of normal tissue.
Qualitative evaluation, the easiest and the most popular approach, involves the visual detection of focal early, strong enhancement with early washout compared with that of normal tissue [ 38].
To this end, we defined a genomic interval extending 0.2 centiMorgan (cM) either side of the 'focal' single nucleotide polymorphism (focal SNP ie strongest association signal) for each confirmed GWAS susceptibility locus for a range of common diseases and traits.
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