Of course even that won't change the B.S.A.'s "focal point" status.
The contrasts listed in Tables 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 are arranged by confounds (confound free, confounded age contrasts), ProM subdomain (ProM proper, vigilance), and ProM cue status (focal, non-focal, indeterminate).
The incidence of febrile seizures with both focal and convulsive status epilepticus features was 1/100 000/year (95% CI 0.5 2) while that for those with both focal and repetitive features was 6/100 000/year (95% CI 4 8).
Proportionally, mortality was highest in neonates, in patients admitted with coma, focal seizures or status epilepticus and among those with complications such as acidosis, hypoglycaemia, hyperkalaemia and impaired renal function, or with bacteraemia and pyogenic meningitis.
Status epilepticus, focal seizures, coma, metabolic acidosis, bacteraemia, and pyogenic meningitis were independently associated with mortality; while status epilepticus, hypoxic ischaemic encephalopathy and pyogenic meningitis were independently associated with neurological deficits on discharge.
Patients with brain abscess may present a myriad of complaints including headache, mental status changes, focal neurologic deficit, fever, and new-onset seizures.
Central neurological failure was defined by any neurological disorder of central origin among impairment of consciousness, seizure with or without status epilepticus, focal neurological signs, encephalopathy, and meningeal symptoms.
The hypothesis linking BBB damage to seizures is in agreement with histological studies that have shown BBB dysfunction in human epileptic tissue and with MRI studies showing changes corresponding to the location of EEG activity in patients with partial status or focal epilepsy [11], [12], [14] [18], [25].
This review summarises the rationale for focal therapy, its current status and future perspectives.
