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Several treatments used in oncology may induce changes in normal bone marrow and in pathologic marrow affected by diffuse or focal pathology.
These distinct patterns of connectivity associated with unilateral hippocampal sclerosis show how a focal pathology influences global network architecture, and how left or right-sided lesions may have differential and specific impacts on cerebral connectivity.
Hepatic and splenic FDG clearances were measured using Patlak-Rutland graphical analysis from ROI over the liver (3 cm) and spleen (2.5 cm), each summed from 20 contiguous cranio-caudal transaxial slices, avoiding any suspected focal pathology in each slice, as previously described [29].
A number of recent studies have assessed conventional MRI in subjects with RIS [3], [4], [5], [6], [32], stressing the similarity of the MRI findings with those of patients with clinically definite MS. In our study, both focal pathology, as expressed by T2-W and T1-W LV, and diffuse tissue damage, as expressed by global brain volume, were comparable in RIS subjects and RRMS patients.
However, CEUS has also been reported in the evaluation of focal pathology in other organs.
We studied THAL and ENT confirming TD focal pathology in THAL, but not ENT.
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Children with diverse focal pathologies and diagnoses were included across all study groups, such as stroke, penetrating head injury and contusions, tumours, cysts and abscesses.
In contrast, infected C3−/− mice displayed a more diffuse, non-focal pathology with increased interstitial involvement (Fig. 3N).
In stark contrast, the interest in extra-focal pathologies appears generally limited and attempts to foster retrospective post-mortem analyses in human epileptics are sparse unless driven by forensic aspects [ 22, 23].
Again, the warping results favor the use of SyN-CCFM for normalizing injured brain with focal gross pathology.
The H-reflex latency, however, is considered to lack sensitivity since a small change from the focal root pathology can be diluted in a relatively long reflex latency.
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