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In our study, only symptomatic focal grade III and IV cartilage lesions in otherwise healthy knees were included.
Defect cartilage and synovial fluid was obtained from donors undergoing either microfracture or autologous chondrocyte implantation for focal grade III and grade IV cartilage defects.
Defect cartilage (n = 3) and synovial fluid (n = 22, age 20 to 48, average 33 years) were obtained from donors undergoing either microfracture or autologous chondrocyte implantation (ACI) for focal grade III and IV cartilage defects (only grade III cartilage was used for chondrocyte isolation).
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To illustrate the clinical utility of the contrast provided by this FLIM instrument, a series of 18 colonic tumour resections were imaged, of which sixteen were shown by subsequent histopathological analysis to be invasive adenocarcinomas and two were serrated adenomas with focal high grade dysplasia.
Surgical pathology showed a malignant solitary fibrous tumor with spindled to epithelioid cells and focal high-grade nuclear atypia.
The surrounding cystic duct showed epithelial cell proliferations in the mucosa with moderate and focal high-grade cellular atypia, outstretching into small branching bile duct.
In T. belangeri, the caudalmost out of three pairs of epibranchial placodes first consists of several focal high-grade thickenings which, in the continued presence of neuroblast delamination, secondarily "unite" into a single solid placode (Washausen et al. 2005).
Recurrent Barrett's multi-focal high-grade dysplasia, over a 10 mm segment length was detected 88 months after esophagectomy in one patient and was successfully ablated with porfimer sodium photodynamic therapy using the methods described elsewhere [ 15].
By comparing the group of patients with diffuse injuries (CTM grades 1 4) versus patients with focal injuries (CTM grades 5 6), there were somewhat higher values for S100B and NSE in CSF in the group presenting diffuse injuries, but not statistically significant.
Histological examination revealed a tubulo-villous adenoma with high grade focal dysplasia.
In the present study, diffuse injuries on CT at admission represented by CTM grades 2 4 showed no significant difference in levels of tissue damage markers compared with patients presenting more focal lesions (CTM grades 5 6).
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