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We designed and built a focal electrical stimulation system as a sham rTMS condition.
Implantable neural prostheses that deliver focal electrical stimulation upon demand are rapidly emerging as an alternate therapy for roughly a third of the epileptic patient population that is medically refractory.
The aim of the present study was to evaluate the effects of transcranial focal electrical stimulation (TFS) on γ-aminobutyric acid (GABA) and glutamate release in the hippocampus under basal conditions and during pilocarpine-induced status epilepticus (SE).
Most of these methods rely on the tight coupling between neuronal activity and regional cerebral blood flow first noted at the end of the 19th century, based on the observation that focal electrical cortical stimulation resulted in localized changes in cerebral hemodynamics.
Evoked EPSCs were obtained by delivering focal electrical stimulation in striatum radium.
Briefly, focal electrical stimulation (ES) of the AI (ESAI) of the C57 mouse was used for cortical activation.
Similar(40)
The majority of atrial premature beats that initiate AF originate from focal ectopic electrical activity in the pulmonary veins (PVs).
Electrical or focal mechanisms of AF include abnormal automaticity, triggered activity, and multiple variable reentrant circuits [ 1, 11].
We hypothesized that human atrial fibrillation (AF) may be sustained by localized sources (electrical rotors and focal impulses), whose elimination (focal impulse and rotor modulation [FIRM]) may improve outcome from AF ablation.
Treatments such as electrical stimulation or focal drug infusion could be given on demand and might eliminate side-effects in some patients taking antiepileptic drugs long term.
With focal epileptic seizures, the abnormal electrical activity arises in a localized group of neurons or network within one hemisphere.
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