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Spreading of labelled metabolites within tissue can disperse locally high metabolite levels, reduce registration of focal activation and contribute to release from brain.
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These data suggest that the stored Ca2+ in the ER/SR is released from RyR in myocytes or from IP3R in other cell types upon stimulation and/or constitutive focal activation [ 17], and is then transferred to mitochondria through the local mitochondrial calcium uniporter.
Vagal slowing was not observed at sites of AF termination.DISCUSSION: PV antral regions where ablation terminated AF before PVI exhibited rotational and focal activation by two independent mapping methods.
To generate the forward data, we simulated a focal activation of ΔHbR = −0.01mM and 1 cm in radius on the right hemisphere of the visual cortex (Figs. 9(a) and 9(b)) as the type of brain activation one would expect from a retinotopic mapping study [ 38].
"We can see this reflected in the very clean focal activation of the primary motor cortex and cerebellum.
The differences between EEG versus MEG spindles may arise from their biophysically-determined differential sensitivity to these different thalamocortical systems, with EEG more sensitive to diffuse activation via the matrix system, and MEG to focal activation via the core system.
This focal activation spread out from the septum and caused the wavefront on the epicardium to be significantly less planar (increased curvature) throughout the remainder of the activation sequence, relative to the more uniform and planar wavefront in the simplified model, particularly evident in the epicardial 58- to 72-ms images.
This is further substantiated by imaging data revealing that peripheral ghrelin administration causes a focal activation of a network of VTA, NAc and lateral hypothalamus in rats [ 39].
Spontaneous focal activation of NKT cells in the liver and kidney with high local levels of IFN-γ will have to be considered in future studies of immune function in these organs.
To zoom in to study a particular time period or specific cell types in vivo, we may apply optogenetic methods to control the intensity and temporal pattern of focal activation 82.
By employing two paradigms that differed widely in musical complexity, we found that improvisation (compared to production of over-learned musical sequences) was consistently characterized by a dissociated pattern of activity in the prefrontal cortex: extensive deactivation of dorsolateral prefrontal and lateral orbital regions with focal activation of the medial prefrontal (frontal polar) cortex.
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