It triggers in veterans of Pink Floyd-related shows an instant tribal recall, filled with visions of flying clocks, prisms and crashing Spitfires.
The Victoria Train Station could be considered one of the Eighth Wonders of the World, so ornate, flying buttresses, clock tower, intricate detail, truly a visual delight.
The Fly clock is $19.95 at Mxyplyzyk, 125 Greenwich Avenue (13th Street).
In today's issue of Cell, a team reports that it has found in mice and humans a close relative of a fruit fly clock gene--the first evidence that some of these genes may have been conserved over the course of evolution.
These studies suggest that electrical membrane properties maybe similarly important in the fly clock and mammalian SCN.
As currently accepted, the fly clock is constituted by interlocked negative transcription/translation feedback loops (TTFLs).
Most recently, an RNAi screen in Drosophila revealed that genes involved in Fe metabolism were important for a functional circadian clock, while a role for haem in the fly clock was not immediately clear (Mandilaras and Missirlis, 2012).
Because KPNB1 was required for rhythmicity in human cells, we investigated the role of the Drosophila ortholog, Fs(2 Ket, ketel, in the fly clock by RNAi followed by locomotor activity monitoring (Mason and Goldfarb, 2009).
Nonetheless, our results indicate that E75 together with UNF (which is not a CLK/CYC target) reinforces the main loop of the core fly clock composed of CLK/CYC and PER/TIM through a feedforward mechanism, showcasing the mechanistic parallels between fly and mammalian clocks.
