Our on-the-fly review: We'd have been happy with an album comprised entirely of Jonny Greenwood sound effects.
Recent studies both in mammalian and Drosophila systems showed that F-actin dynamics can be regulated by YAP1 (Yorkie in flies) (reviewed in Matsui and Lai, 2013; Moroishi et al., 2015).
Flier reviewed his studies of adipsin (41), a circulating protease mainly produced in fat, with levels reduced in obesity in rodents but not in humans.
In summary, centrosomes contribute to mitotic fidelity, cytokinesis and asymmetric cell division, but this is not essential for the development of the flies (reviewed in [ 16]).
For example, manipulations of genes involved in the insulin signaling and the target-of-rapamycin pathways have been causally linked to lifespan regulation in flies (reviewed in ).
Promastigote cultures are incubated generally at approximately 26 27°C also imitating the conditions inside the gut of the sand fly (reviewed by [ 13, 14]).
This gap is being filled, however, by a number of recent studies that have led to the characterization of physiological roles for different organs in energy homeostasis in the fly (reviewed in [ 4- 9]).
The regulation of cell death is a critical aspect of nervous system development which has also been linked to the development of sexual dimorphism in fruit flies (reviewed by [ 9]).
Flier reviewed studies in which fetal stem cells developed into neurons, some expressing POMC and leptin-activated STAT3, which, when transplanted into db/db mice lacking the leptin receptor, led to weight loss and improved glycemia, suggesting that it may be possible to "rewire the obese brain".
Numerous models of human disease have been established in the fly (reviewed in Pandey and Nichols 2011), including transgenic models of diseases ranging from neurodegeneration/retinal degeneration (Bilen and Bonini 2005; Ryoo et al. 2007; Lessing and Bonini 2009; Yu and Bonini 2011) to cancer (Rudrapatna et al. 2012).
