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Furthermore, to avoid biologically implausible solutions, we added further constraints to iex GFMM_ BΘ linking the flux through to one of the organism's reactions with the respective biomass reaction (see Materials and Methods and Figs. S2-S4 ).
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Quantifying the rates and timing of landscape denudation provides a means to constrain sediment flux through time to offshore sedimentary basins.
As a result, A. succinogenes must rely on gluconeogenic flux through PEPCK to make PEP from malate and fumarate.
(A ) Probability density function (PDF) of the Warburg Effect (WE) defined as the ratio of flux through LDH to that of flux into the mitochondria.
Deletion of pgi was also found in many of the strain designs for ethanol production, suggesting re-direction of flux through glycolysis to the pentose phosphate (PP) pathway or Entner-Doudoroff (ED) pathway.
Another strategy could be to increase flux through C4 photosynthesis to produce increased levels of polymer while limiting agronomic penalties.
While allosteric regulation of wild-type CS may have been able to adjust flux through this reaction to the very low levels that are optimal under these conditions, this was apparently not possible with the gltA1 mutation already present.
This would enable Ca2+ fluxes through VSCC to activate PKA in response to EphA5 receptor activation.
Rapidly proliferating cancer cells increase flux through anabolic pathways to build the mass necessary to support cell division.
To find such mechanisms, we reduced flux through the proteasome to the point of toxicity with specific inhibitors and performed genome-wide screens for mutations that allowed cells to survive.
A null mutant allele, if homozygous or hemizygous, results in no functional enzyme and will cause E i for that enzyme to be zero, which in turn causes the flux through the pathway to be zero.
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