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The maximum flux route of chlorine is the polyvinyl chloride (PVC) production path: NaCl→Cl2→HCl→PVC.
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Most labeling studies focus on skeletal representations of central metabolism and ignore many flux routes that could contribute to the observed isotopic labeling patterns.
The values of C x J y for each reaction were assigned based on possible flux routes reaching from glucose, and are partitioned by a slash.
This indicates the problems associated with analysis of the null-space and explains why alternative definitions for steady-state flux routes in metabolic networks have been developed; these are introduced and discussed in sections 4 to 9.
Without modeling of regulation, product inhibition, and metabolite toxicity, the multiple re-entry points in the superpathway and the reversible nature of the pentose phosphate pathway allow carbon flux to route around deletions with weak growth.
GAPDH acts as an enzymatic metabolic switch; once inactivated, the cytoplasmic carbohydrate flux re-routes from glycolysis to the pentose phosphate pathway [14].
The decomposition procedure would identify the flux adjustment routes (i.e. eigenfluxes) by which evolution would be achieved.
Only shift of carbon flux to succinate route is not enough to control the formation of other undesired metabolites.
Bax inhibitor 1-like (Additional file 12) post-translationally activates the C4 hydrolase [ 48] thus promoting flux through this route for acylation by very long-chain fatty acids (VLCFA; [ 49]).
These results suggest that the Entner-Doudoroff pathway is functional, although it has been reported that for aerobic cultures with glucose the carbon flux through this route is not very high [ 52, 53].
When the Acs2p-catalysed reaction is eliminated, flux simply re-routes through the Acs1p reaction.
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