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Ab mutant cells also had reduced overall GFP-Atg8a levels compared to neighboring wild type cells, suggesting that some mutations may lead to enhanced autophagosome-lysosome fusion and increased autophagic flux, causing a high rate of turnover of the fusion protein.
In most cases there is an impairment of autophagic flux, causing a secondary accumulation of autophagy substrates such as polyubiquitinated proteins, p62/SQSTM1 and dysfunctional mitochondria, on one end, and an increase in factors involved in autophagosome formation, such as BECN1, as an attempt to compensate for the impaired autophagic flux, on the other.
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Parametric studies of numerical dynamos show that increasing convection vigor (which is controlled by the mean CMB heat flux) causes a transition from dipole dominated non-reversing to multipolar reversing dynamos (Aubert et al. 2009; Christensen and Aubert 2006; Kutzner and Christensen 2002).
If reduced flux causes a high fitness cost, the result is a large cost of hemizygosity.
It was demonstrated that lack of glutamine coupled with reduced glycolytic flux caused a reduction in the sialylation and antennarity of the N-linked glycans attached to HCG, an event mediated by the decrease in the intracellular pool of UDP-GlcNAc.
This region, next to the original QC and coinciding with the redifferentiation of the new QC, presents a fold increased auxin concentrations within 20 min. This is due to the reflux-loop generating constantly high fluxes, causing a rapid replenishment of the cells just above the removed QC.
A linear relationship between fitness and flux implies that a given reduction in flux causes an equal reduction in fitness.
If the coupling of the fluxes causes a species to be moved against its concentration difference, the transport is known as uphill transport.
Bursts of X-rays and increased solar cosmic ray fluxes caused an increase in ionospheric absorption manifesting itself in data from vertical sounding stations as enhancements of the lowest frequency of reflections up to 4 6 MHz at the daytime and as the disappearance of reflections in the ionograms of high latitude stations.
This study evaluates the performance of empirical correlations for the a-priori prediction of the heat flux causing the onset of DHT in heated vertical tubes with an internal upward flow of supercritical water and proposes a new correlation.
We hypothesized that this phenomenon is due to increased protein synthetic flux, causing folding stress that leads to a bottleneck in the protein secretion pathway.
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