A linear relationship between fitness and flux implies that a given reduction in flux causes an equal reduction in fitness.
Ab mutant cells also had reduced overall GFP-Atg8a levels compared to neighboring wild type cells, suggesting that some mutations may lead to enhanced autophagosome-lysosome fusion and increased autophagic flux, causing a high rate of turnover of the fusion protein.
It was demonstrated that lack of glutamine coupled with reduced glycolytic flux caused a reduction in the sialylation and antennarity of the N-linked glycans attached to HCG, an event mediated by the decrease in the intracellular pool of UDP-GlcNAc.
In most cases there is an impairment of autophagic flux, causing a secondary accumulation of autophagy substrates such as polyubiquitinated proteins, p62/SQSTM1 and dysfunctional mitochondria, on one end, and an increase in factors involved in autophagosome formation, such as BECN1, as an attempt to compensate for the impaired autophagic flux, on the other.
If the coupling of the fluxes causes a species to be moved against its concentration difference, the transport is known as uphill transport.
This region, next to the original QC and coinciding with the redifferentiation of the new QC, presents a fold increased auxin concentrations within 20 min. This is due to the reflux-loop generating constantly high fluxes, causing a rapid replenishment of the cells just above the removed QC.
Bursts of X-rays and increased solar cosmic ray fluxes caused an increase in ionospheric absorption manifesting itself in data from vertical sounding stations as enhancements of the lowest frequency of reflections up to 4 6 MHz at the daytime and as the disappearance of reflections in the ionograms of high latitude stations.
Thermodiffusion or Soret effect, corresponding to a mass flux caused by a temperature gradient applied to fluid mixture, has been taken into account in many porous media applications, particularly in chemical engineering and geophysics.
We consider the ND-like features of degenerating NB cells attributable to an interruption of autophagic flux caused by a loss of intact lysosomes through LAPTM5-mediated lysosomal destabilization, although we can not exclude the existence of some other mechanism, given results of studies where autophagic flux or lysosomal degradation were genetically disrupted in mice [27], [28].
