Sentence examples for flux analysis has from inspiring English sources

Metabolic Flux Analysis has turned out to be a powerful approach for studying and engineering metabolic networks.

At the metabolic level, flux analysis has been used to monitor changes in the metabolic state that could affect the successful outcome of cell cultures.

Though metabolic flux analysis has been somewhat limited in application towards pharmaceutical production, the overall goal is to: (1) have a better understanding of the organism and/or process in question, and (2) provide a rational basis to further engineer (on both metabolic and process scales) improved pharmaceutical production in these organisms.

Metabolic flux analysis has been applied since to the pathway [ 25- 27].

C-Metabolic flux analysis has been increasingly used to observe in vivo fluxes in mammalian systems [ 34].

C-based metabolic flux analysis has become a highly relevant tool for systems biology of microbial metabolism.

Recently developed and applied technologies for metabolic flux analysis have been described.

Two methods using optimization procedure, 13C-based flux analysis and constraints-based flux analysis, have been used generally on the basis of stoichiometry of metabolic reactions and mass balances around intracellular metabolites under pseudo-steady state assumption.

The focus of this review article is to present how experimental and computational methods of metabolic flux analysis have matured, mirroring the maturation of the metabolic engineering field itself, while highlighting some of the successful applications towards both small- and large-molecule pharmaceuticals.

Typical networks used for metabolic flux analysis have a number of fluxes in the range of 100, but a number of free fluxes that is typically in the region of 10.> To give a general idea about the computational complexity of the algorithm, the total CPU times of the estimations for the small-scale and medium-scale network for both fixed and optimal K matrices are shown in Table 4.

However, the accuracy of this reference, when calculated with flux balance analysis, has not been studied in detail before.