Especially in biomedical, nanomaterials were designed for various applications such as fluorescent nanomaterials for disease diagnosis [1, 2], tissue engineering [3], bioimaging [4], biosensors [5] and implants [6].
To establish an in vitro study for drug screening of circulatory diseases, fluorescent bead accumulation on EC layers was examined under circulating flow conditions.
However widespread implementation of fluorescent microscopy (FM) in disease endemic settings has not been realized.
Patients were considered to have high-risk disease if fluorescent in situ hybridization studies demonstrated one of the following abnormalities: t(4 14), t(14 16), t(14 20) or loss of p53 gene locus (del17p or monosomy 17).
Similarly, direct fusion of a fluorescent protein to the disease-causing transgene has been employed as a read-out of transgene expression, but can also be used as a marker for protein aggregation.
In a study with patients receiving cetuximab for advanced CRC, 23% of patients were found to have HER2 fluorescent in-situ hybridisation positive disease (Finocchiaro et al, 2007).
COPD: chronic obstructive pulmonary disease; DFA: direct fluorescent antigen detection; EIA: enzyme immunoassay; NP: nasopharyngeal; pH1N1: pandemic 2009 H1N1 influenza; RT-PCR: reverse transcriptase polymerase chain reaction; TIBDN: Toronto Invasive Bacterial Diseases Network.
ATP, adenosine 5'-triphosphate; RNAi, RNA interference; AMP, adenosine 5'-monophosphate; ETC, electron transport chain; PD, Parkinson's disease; GFP, Green fluorescent protein; DMSO, dimethyl sulfoxide; NLS, nuclear localisation signal.
Ang II: angiotensin II; ARF: acute renal failure; BMSC: bone marrow-derived stem cells; BrdU: bromodeoxyuridine; EMT: epithelial mesenchymal transition; EPC: endothelial progenitor cells; ESKD: end stage kidney disease; GFP: green fluorescent protein; MM: metanephric mesenchyme; RAS: renin-angiotensin system; UB: ureteric bud The authors declare that they have no competing interests.
Given that peroxynitrite (ONOO−) is profoundly associated with health and diseases, a new fluorescent probe ABT was designed and synthesized for detection of ONOO−.
