In conclusion, our data suggest that a high lipophilic index reflecting a lower fluidity of erythrocyte membranes is associated with a higher risk of type 2 diabetes.
In support of this idea, we determined that IFITM1 decreases membrane fluidity and that this event is associated with inhibition of IAV-induced cell-to-cell fusion; these data are consistent with those recently generated using orthologous approaches (Li et al., 2013).
It is important to note that this phase is associated with membrane fluidity, which is a prerequisite in the study of peptide-membrane interactions.
Investigation of diabetic erythrocytes with cardiovascular complications is associated with lowered membrane fluidity when compared to healthy controls.
For instance, PrPSc accumulation promotes an increase in the level of free cholesterol, and is associated with a reduction in membrane fluidity, which may amplify the duration and/or strength of signaling.
Capacitation is associated with changes in sperm intracellular ion concentrations, plasma membrane fluidity, changes in metabolism, tyrosine phosphorylation of multiple proteins, and acquisition of a different motility pattern [11], [37].
The clear changes of membrane fluidity in SMPDL3B knockdown or knockout cells strongly suggested that the TLR-modulating activity of SMPDL3B is associated with a change in macrophage lipid composition.
A high lipophilic index, reflecting lower membrane fluidity, may be associated with a higher risk of type 2 diabetes.
The dynamics of molecules in membranes (order parameter, degree of freedom of lipid aliphatic chains, lateral and rotational diffusions), often referred to as membrane fluidity, have been associated with modulation of the activity of many important functions of proteins in biological membranes (for a review, see 3).
Increased transmembrane potential, surface area, and membrane fluidity, all of which are associated with neoplastic cells, may also contribute to the selective cytotoxic activity of certain CAPs [ 9].
