Similar(58)
We extracted data on: study designs, settings, sample size, participants (diagnoses, age range), shock definitions, treatments and comparisons (types of fluids, timing, volumes and fluid rates), cointerventions and proportion of patients experiencing the events of interest in each treatment group.
This difference is significant for different components of the H3 bundle, with percentage of compliance reported as follows: H3 blood cultures ED 75%%, W 30%%, EXT 25%% (p = 0.001), H3 lactate ED 83%%, W 30%%, EXT 63%% (p = 0.00), H3 antibiotics ED 52%%, W 9 %, EXT 20%% (p = 0.001), with the exception of the fluid therapy timing (NS).
Unfortunately, we did not collect precise information on such fluid administration (timing, amount or number of patients so treated) because of the logistic difficulty of collecting such detailed information while attempts were being made to save the life of the patients.
Many are poorly representative of the human condition in terms of the type of septic insult (e.g. injection of endotoxin), study duration (hours rather than days), lack of any resuscitation (such as fluid), and the timing of putative therapies (often given at or preceding the insult rather than after establishment of organ dysfunction, as would be the case in patients).
Though there is a consensus on the need for adequate fluid therapy, the timing, type, and quantity of fluid resuscitation remain controversial.
Although no data were available on fluid balance by timing of RRT, those receiving earlier RRT (< 2 days after ICU admission) had lower 60-day mortality (44.8% versus 64.6%; P < 0.01), despite more oliguria and greater severity of illness.
Fluids given for volume resuscitation (total amount, type of fluids and their timing), vasoactive drugs, and use of pulmonary artery catheter were recorded.
Resurfaced rotors, all fluids replaced, new timing belt, all that.
Data extracted, in duplicate using a standard form, included general study characteristics (authors, design), as well as information about the study population (age, setting, condition/diagnosis), intervention (fluids compared, intervention timing and volume) and outcomes (author definition of outcome, point estimates, summary statistics, author conclusions).
Integrating hemodynamic parameters, timing and fluid volume suggests that fluid requirement varies between patients, and very early hemodynamic monitoring may serve at tailoring fluid resuscitation in critically ill burn patients.
The type and timing of fluid administration have been found to be an important aspect of fluid efficacy in recruiting microcirculation [ 39, 41].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com