Sentence examples for fluid simulant models from inspiring English sources

The dissolution rate of glass fibers has been shown to be pH sensitive using in vitro lung fluid simulant models.

These results are different from those obtained using in vitro lung fluid-simulant models where dissolution is faster at higher pH.

Negligible erosion of the gel in the presence of vaginal fluid simulant suggests prolonged retention.

Even after 24 h of incubation in vaginal fluid simulant more than 35% of the originally encapsulated drug was retained in the hydrogel.

In vitro release studies have demonstrated that even after 24 h of incubation in vaginal fluid simulant (at 37 °C) more than 30% of the originally entrapped clotrimazole (or 50% of metronidazole) was still retained in the gel.

Both types of liposomes were characterised and compared for particle size, polydispersity, entrapment efficiency, and tested for in vitro stability in media that mimic human vaginal conditions (buffer, pH 4.5, and vaginal fluid simulant).

The vaginal film formulation was fast-dissolving (<10 min in 1 mL of vaginal fluid simulant), stable up to at least one month and safe toward epithelial cells and lactobacilli.

Tablets comprising these thiolated polymers and nystatin demonstrated a high stability in vaginal fluid simulant pH 4.2 and an increase in weight by swelling whereas control tablets comprising unmodified poly acrylic acid) disintegrated and dissolved.

All liposome preparations were characterized and compared for particle size, polydispersity, encapsulation efficiency and tested for in vitro stability in different media chosen to simulate human vaginal conditions: buffer, pH 4.5 (corresponding to normal human vaginal pH), vaginal fluid simulant (medium developed so as to mimic the fluid produced in the vagina) with or without mucin.

This study is designed to test the hypothesis that tenofovir (TNF) or tenofovir disoproxil fumarate (TDF) loaded nanoparticles (NPs) prepared with a blend of poly(lactic-co-glycolic acid) (PLGA) and methacrylic acid copolymer (Eudragit® S-100, or S-100) are noncytotoxic and exhibit significant pH-responsive release of anti-HIV microbicides in the presence of human semen fluid simulant (SFS).

A multiple regression model was used to evaluate the relative importance of major parameters tested in this study such as pH of the vaginal fluid simulant, the relative complexity of the biological matrix, the assay type, and technical performance parameters reflecting interassay and inter-replicate (intra-assay) reproducibility of cytokine recovery.