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Amniotic fluid matrix metalloproteinase-9 may serve as a clinical marker for the onset of both preterm and term labor.
To test this hypothesis, we examined the relationship between levels of amniotic fluid matrix metalloproteinase-8 and funisitis.
Conclusions: There is a strong association between increased levels of amniotic fluid matrix metalloproteinase-8 and funisitis.
Amniotic fluid matrix metalloproteinase-2 levels (both latent and active forms) remained relatively constant throughout pregnancy and in labor.
Chorioamnionitis and amniotic fluid matrix metalloproteinase 9 concentrations were correlated with tissue inhibitor of metalloproteinase 1 levels.
Although oral fluid is easy to collect there is considerable inter-sample variability in the fluid matrix that provides issues when developing a testing methodology.
Although this fluid is easy to collect there is considerable inter-sample variability in the fluid matrix that generates issues when developing a testing methodology [11].
Results: The detectable presence of amniotic fluid matrix metalloproteinase 9 was independently associated with intra-amniotic infection, labor, cervical dilatation, and spontaneous rupture of membranes.
Conclusion: Increased amniotic fluid matrix metalloproteinase 8 concentrations identify patients at risk for intra-amniotic infection, impending preterm delivery, and adverse neonatal outcome.
The objective of this report is to perform recovery studies to evaluate potential body fluid matrix interferences for commonly requested chemistry analytes.
We propose that determination of amniotic fluid matrix metalloproteinase-8 concentrations may assist the assessment of the fetal inflammatory status, thereby eliminating the need for fetal blood sampling.
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