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Thirst, therefore, would seem to be triggered by mechanisms controlling the fluid integrity both within and around the cells of the body.
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Pleural fluid DNA integrity index is a promising diagnostic biomarker for identification of MPEs, including mesothelioma.
Our results indicate that pleural fluid DNA integrity index is a promising diagnostic biomarker for MPEs.
Pleural fluid DNA integrity index was higher in MPE compared with benign effusions (1.2 vs. 0.8; p<0.80.8.
We also evaluated the ability of pleural fluid DNA integrity index and mesothelin to distinguish mesothelioma from benign effusions.
Additionally, we showed that in cytology negative effusions, elevated pleural fluid DNA integrity index had 81% PPV.
Importantly, almost a third of false positive pleural fluid DNA integrity index results were due to parapneumonic effusions.
In the detection of mesothelioma, at a specificity of 90%, pleural fluid DNA integrity index had similar sensitivity to pleural fluid and serum mesothelin (75% each respectively).
Nonetheless, our data demonstrate that pleural fluid DNA integrity index is comparable in sensitivity to pleural fluid and serum mesothelin in diagnosing mesothelioma.
Hence pleural fluid DNA integrity index provides valuable additional information to pleural fluid cytology, particularly in subjects with either inconclusive or "suspicious" cytology results.
Median pleural fluid DNA integrity index was not significantly different according to gender, smoking, pleural fluid biochemical or cytology classification in these subjects (Table 4).
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