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At station #3 (BH), first formation fluid indication was observed in <20 min.
In BH and FAT stations, first fluid indication was obtained in 18 and 27 min respectively after pumping was initiated.
Taking these data into account would yield a combined risk ratio of 1.12 (0.88 to 1.42 95% CI) in the subgroup of trials with 'high probability of correct fluid indication'.
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First formation fluid indications were observed in <10 min.
Starting from the investigation of different cannula designs, numerically assessing the local fluid dynamics, indications can be drawn to support both the design phase and the device optimal clinical use, in order to limit risks of biomechanical origin.
End points specific to this group included gross and histopathology, hematology, serum chemistry, and evaluations of bronchoalveolar lavage fluid for indications of cytotoxicity [lactate dehydrogenase (LDH) activity] and inflammation (total protein, total and differential nucleated cell counts), and splenocyte proliferation in response to mitogen in vitro.
Extensive laboratory diagnostics of the patients' blood and cerebrospinal fluid revealed no indications for inflammatory or neurodegenerative processes.
The correlation of these cellular and biochemical alterations in the bronchoalveolar lavage fluid with morphological indications of damage has served to validate this method of detecting acute lung injury.
To ensure appropriate indication of fluid administration, evaluation of fluid responsiveness by dynamic parameters is suggested, although it requires specific conditions not always present in ICU patients.
Increased blood volume is an indication that fluid is being lost from the circulation into the extracellular fluid.
From a practical point of view, patients with an Eadyn value <0.89 require vasopressors along with fluids to increase MAP, whereas patients with an Eadyn value ≥0.89 show an indication that fluid loading alone will increase blood pressure.
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