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That same year he and Delbrück devised the fluctuation test, which provided experimental evidence that phage-resistant bacteria were the result of spontaneous mutations rather than a direct response to changes in the environment.
He shared the award with biologists Salvador Luria and Max Delbrück, whose experiments with the T1 phage in 1943 (the fluctuation test) showed that phage resistance in bacteria was the product of spontaneous mutation and not a direct response to environmental factors.
The mutagenicity activity was estimated with the Ames fluctuation test.
Furthermore, possible genotoxic effects of photoderivatives were investigated using SOS chromotest and Ames fluctuation test.
Thermal-load fluctuation test is planned to demonstrate the stable reactor dynamics and to gain the test data for validation of the plant dynamics code.
Different from the traditional evaluation model based on single or a few constituents, the fingerprint data of every parameter fluctuation test was processed with Principal Component Analysis (PCA) to comprehensively assess the performance of ethanol precipitation.
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Fluctuation tests were performed as previously described [4], [57] with modifications.
The average and standard deviation of 8 fluctuation tests performed with 4 independent transformants of each strain are shown.
Fluctuation tests demonstrate that resistance to specific anti-tuberculosis drugs arises spontaneously at a rate of one in 106 109 cell divisions, depending on the drug [8], [9].
We calculated the spontaneous genomic mutation rate of H. salinarum NRC-1 using fluctuation tests targeting genes of the uracil monophosphate biosynthesis pathway.
Fluctuation tests were performed as described above and cultures were plated in toto on GN101 medium supplemented with 50mg/L uracil, 50µM mevinolin, and 350mg/L 5-FOA.
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