We experimentally prove the existence of this relationship between the fluctuations of cellular behavior (noise) in single cells and the cellular response to an external stimulus using bacterial chemotaxis in E. coli as a model system.
The continued extension and retraction of KC lamellipodia manifested itself as small fluctuations of cellular volume and surface area over time.
An increase in the fluorescence of the cells confirmed that BODIPY-appended calix[4]arene sensed the fluctuation of the cellular pH during early cell apoptosis.
AMPK plays an important role in fatty acid oxidation, glucose uptake, and hepatic lipogenesis by reacting to the fluctuation of the cellular AMP ATP ratio (Hardie et al., 2012; Inoki et al., 2012).
In keeping with Nox activity, finely controlled, modest fluctuations of the cellular redox status have been shown to be capable of reversible modulation of signalling cascades.
Here, dynamical noise can play a role due to the low concentrations of molecular species and random thermal fluctuations of the cellular environment.
Physico-chemical stochastic fluctuations of the cellular environment introduces small variability in the spliceosome efficiency and perhaps results in imperfect selection of splice sites that eventually produces many lowly expressed alternative transcripts, as is observed in our data [ 6, 13, 19, 33, 43, 44].
In the rat model of LID, fully denervated animals show a high sensitivity to the fluctuations of extra-cellular DA induced by l-dopa treatment (Dethy et al., 1999), often showing dyskinetic behaviours even after the first l-dopa dose (Winkler et al., 2002 and Vinuela et al., unpublished data).
One possible source of stochasticity is the effect of cellular fluctuations on the activity or stability of a protein or RNA transcript.
